Occupational Medicine & Health Affairs
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Kazunari K Yokoyama
Taiwan
Publications
Two-hit Reprograming of Induced Pluripotent Stem Cells
Endogenous and exogenous stresses produce reactive oxygen species (ROS) in cells, and these can cause DNA damage, apoptosis, autophagy, and senescence. The reprogramming of somatic cells to produce induced pluripotent stem cells (iPSCs) initially requires ROS production and then represses the endogenous expression of tumor suppressor factors such a... Read More»
Commentary: Occup Med Health Aff 2014, 2:168
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