中国P站

Abstract

Poorly soluble drugs pose significant challenges for oral drug delivery, often leading to low bioavailability. This compilation reviews advanced formulation strategies designed to overcome these limitations. Techniques discussed include nanocarrier systems (mesoporous silica nanoparticles, SLNs, NLCs, liposomes), amorphous solid dispersions (ASDs) produced via spray drying and hot-melt extrusion, lipid-based formulations (SNEDDS), cyclodextrins, mucoadhesive nanoparticles, and particle size reduction technologies. These methods aim to enhance drug solubility, dissolution rate, and absorption, thereby improving oral bioavailability and therapeutic efficacy.