Allergic Immune Responses: Mechanisms, Development, and Treatment
Received Date: Sep 01, 2025 / Accepted Date: Sep 29, 2025 / Published Date: Sep 29, 2025
Abstract
Allergic immune responses are characterized by hypersensitivity to environmental antigens, mediated by IgE antibodies and
T helper 2 (Th2) cells, leading to mast cell and basophil activation. Genetic, environmental, and microbiome factors influence
susceptibility. The gut microbiome’s role in immune maturation and allergy is significant. Mast cells, Th2 cells, eosinophils, innate
lymphoid cells (ILCs), and basophils are key cellular players. Allergen immunotherapy (AIT) induces tolerance, while biologics
targeting specific pathways offer novel treatments. The ’allergic march’ describes disease progression, emphasizing the need for
early intervention.
Citation: Petersen DL (2025) Allergic Immune Responses: Mechanisms, Development, and Treatment. Immunol Curr Res 09: 281. Doi: 10.4172/icr.1000281
Copyright: © 2025 Dr. Lars Petersen This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse, distribution and reproduction in any medium, provided the original author and source are credited.
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