Anthocyanin’s and Browning of the White Adipose Tissue: Role of Mitochondria and Mechanisms of Action
Received Date: Aug 27, 2024 / Published Date: Feb 09, 2026
Abstract
Emerging evidence supports the beneficial effects of Anthocyanins (AC), especially cyanidin and delphinidin consumption, on obesity-associated impaired mitochondrial biogenesis, thermogenesis, and function. AC and their gut metabolites have been shown to improve mitochondrial number via activation of key signaling pathways, including β3-AR/PKA/p38, cAMP/PKA, AMPK/PGC-1α, and AMPK/SIRT-1, which ultimately activate master regulators of the White Adipose Tissue (WAT) browning, i.e. PGC-1α, PRDM16, PPARγ, and UCP-1. Furthermore, select AC have been shown to mitigate obesity-associated mitochondrial dysfunction via modulation of mitochondrial fusion, fission, and mitophagy. A limited number of in vitro and pre-clinical studies is currently available on the above AC actions which have provided promising initial evidence. Further research is needed to fully understand the AC therapeutic potential in mitigating obesity-associated mitochondrial dysfunction.
Keywords: Anthocyanins, Cyanidin, Adipose tissue, Mitochondria, Obesity
Citation: Cremonini E (2026) Anthocyanin’s and Browning of the White Adipose Tissue: Role of Mitochondria and Mechanisms of Action. J Obes Weight Loss Ther 16: 889 Doi: 10.4172/2165-7904.1000889
Copyright: © 2026 Cremonini E. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
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