Autoimmune Disease: Complex Causes, Immune Attack, New Therapies
Received Date: May 01, 2025 / Accepted Date: May 29, 2025 / Published Date: May 29, 2025
Abstract
Autoimmune diseases arise from a breakdown in self-tolerance, causing the immune system to attack the body’s own tissues.
Pathogenesis is multifactorial, involving genetic predisposition, environmental triggers like infections and gut microbiome dysbiosis,
and immune cell dysregulation. Aberrant T cell and B cell activation, innate immune cell dysfunction, epigenetic modifications, and
genetic factors contribute to chronic inflammation. The tumor necrosis factor receptor superfamily also plays a role. Understanding
these complex interactions is key to developing effective therapies.
Citation: Kowalska DA (2026) Autoimmune Disease: Complex Causes, Immune Attack, New Therapies. Immunol Curr Res 09: 264. Doi: 10.4172/icr.1000264
Copyright: © 2026 Dr. Anna Kowalska This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permitsunrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
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