Auto-inflammatory Disorders: Genetic Causes and Targeted Therapies
Received Date: Nov 01, 2025 / Accepted Date: Dec 01, 2025 / Published Date: Dec 01, 2025
Abstract
Auto-inflammatory disorders (AIDs) are a group of genetic conditions characterized by recurrent, unprovoked inflammation re
sulting from innate immune system dysregulation. Manifestations range from fever and rash to arthritis, with potential for organ
damage. Research focuses on genetic diagnosis and targeted therapies. Key AIDs discussed include Familial Mediterranean Fever
(FMF), Cryopyrin-Associated Periodic Syndromes (CAPS), and Deficiency of Interleukin-1 Receptor Antagonist (DIRA), often
involving inflammasome pathways and IL-1 signaling. Management strategies include IL-1 blockade and other targeted agents, re
quiring a multidisciplinary approach. Genetic advancements, including next-generation sequencing, are crucial for accurate diagnosis
and understanding the broad spectrum of AIDs.
Citation: Popescu DE (2025) Auto-inflammatory Disorders: Genetic Causes and Targeted Therapies. Immunol Curr Res 09: 286. Doi: 10.4172/icr.1000286
Copyright: © 2025 Dr. Elena Popescu This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permitsunrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
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