中国P站

Abstract

Barrier immunology plays a crucial role in maintaining homeostasis and protecting against infections at mucosal and respiratory surfaces. The dynamic interplay between host immune mechanisms and microbial communities shapes immune responses, influencing both health and disease. The epithelial barriers in the gut, lungs, and skin serve as the first line of defense, integrating innate and adaptive immunity while interacting with commensal microbiota. Disruptions in these interactions contribute to inflammatory diseases, infections, and autoimmune conditions. Advances in immunology and microbiome research have revealed how microbial metabolites, immune signaling, and epithelial integrity impact disease susceptibility and progression. Understanding these mechanisms provides insights into novel therapeutic strategies, including probiotics, microbiota-targeted therapies, and immune modulation. This review explores the fundamental aspects of host-microbe interactions in mucosal and respiratory immunity, highlighting their implications in maintaining health and contributing to diseases such as inflammatory bowel disease (IBD), asthma, and chronic obstructive pulmonary disease (COPD).