BCRRepertoire Diversity: Generation, Refinement, and Therapeutics
Received Date: May 01, 2025 / Accepted Date: May 29, 2025 / Published Date: May 29, 2025
Abstract
The B cell receptor (BCR) repertoire’s diversity is crucial for adaptive immunity, generated by V(D)J recombination, junctional
diversification, and somatic hypermutation. These processes, along with selection mechanisms, shape the repertoire’s specificity and
affinity. BCR signaling is vital for B cell activation and differentiation, with dysregulation linked to immune disorders. Genetic
factors and T follicular helper cell interactions further influence B cell responses. Therapeutic monoclonal antibodies highlight
the clinical significance of BCR specificity. Alterations in the BCR repertoire are implicated in autoimmune diseases, suggesting
potential diagnostic and therapeutic targets.
Citation: Dubois DC (2025) BCR Repertoire Diversity: Generation, Refinement, and Therapeutics. Immunol Curr Res 09: 261. Doi: 10.4172/icr.1000261
Copyright: © 2025 Dr. Claire Dubois This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse, distribution and reproduction in any medium, provided the original author and source are credited.
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