Caloric Restriction: Health, Longevity, Disease Prevention
Received Date: Oct 01, 2025 / Published Date: Oct 29, 2025
Abstract
Caloric restriction (CR) significantly impacts metabolic health, neuroprotection, and overall longevity by improving insulin sensitivity, reducing inflammation, and enhancing cellular repair. Mechanisms involve sirtuin activation, autophagy, proteome changes, and gut microbiome modulation. While CR reduces body weight and fat mass, it may decrease bone mineral density and requires careful management for skeletal muscle health. Ongoing research explores caloric restriction mimetics as a way to achieve these antiaging and disease-preventive benefits without strict dietary changes, offering promising strategies for healthy aging and combating age-related diseases.
Citation: Nakamori H (2025) Caloric Restriction: Health, Longevity, Disease Prevention. jowt 15: 851.
Copyright: 漏 2025 Haruto Nakamori This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
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