Cancer Stem Cells: A Key Target For Endometrial Cancer
*Corresponding Author: Dr. Jacob Roberts, Sydney Cancer Research Institute, Australia, Email: jacob.roberts@outlook.comReceived Date: Jun 04, 2025 / Published Date: Jun 30, 2025
Citation: Roberts DJ (2025) Cancer Stem Cells: A Key Target For Endometrial Cancer. Current Trends Gynecol Oncol 10: 277.
Copyright: 漏 2025 Dr. Jacob Roberts This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited
| Peer-reviewed Full Article 
Abstract
Cancer stem cells (CSCs) play a pivotal role in endometrial cancer (EC) progression, metastasis, and recurrence. This review synthesizes current understanding of CSC markers, functional significance, and therapeutic strategies targeting this resilient cell population. Key markers like SOX2 and OCT4 are linked to aggressive features, while CSC heterogeneity and the tumor microenvironment present therapeutic challenges. Signaling pathways, aldehyde dehydrogenase activity, and microRNAs regulate CSC properties and drug resistance. Strategies to overcome CSC-mediated immune evasion are also crucial for enhancing immunotherapy efficacy in EC.
