Central Nervous System Infections: Diagnosis, Treatment, and Resistance
Received Date: Nov 01, 2025 / Published Date: Dec 01, 2025
Abstract
This compilation reviews the management of diverse central nervous system (CNS) infections. It emphasizes prompt diagnosis,
appropriate antimicrobial selection considering drug penetration, and empiric therapy guided by epidemiology. Key treatments in
clude penicillin and cephalosporins for bacterial meningitis, vancomycin for MRSA, and acyclovir for HSV encephalitis. Adjunctive
dexamethasone may reduce sequelae in bacterial meningitis. Fungal meningitis, particularly cryptococcosis, requires combination
therapy. Neurosyphilis treatment involves high-dose penicillin G. Research explores optimal antibiotic durations for bacterial menin
gitis, while antimicrobial resistance poses a growing threat. Viral encephalitis management prioritizes early acyclovir. Tuberculous
meningitis requires multi-drug regimens, andListeriamonocytogenesmeningitisneedspromptampicillin. Antimicrobialstewardship
is crucial for combating resistance and optimizing patient outcomes.
Citation: Petrou G (2025) Central Nervous System Infections: Diagnosis, Treatment, and Resistance. JNID 16: 597.
Copyright: 漏 2025 George Petrou This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted聽use, distribution and reproduction in any medium, provided the original author and source are credited.
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