Central Sensitization: A Key Chronic Pain Mechanism
Received Date: Aug 04, 2025 / Published Date: Aug 29, 2025
Abstract
Central sensitization (CS) is a key mechanism in chronic pain, characterized by amplified neuronal signaling and hypersensitivity to stimuli. It involves peripheral and central nervous system changes, including glial cell activation and spinal cord plasticity. CS contributes to various chronic pain disorders. Treatments often combine pharmacological agents with non-pharmacological therapies. Ongoing research aims to identify biomarkers and targeted interventions, acknowledging the influence of brain alterations and psychological factors.
Keywords: Central Sensitization脥戮 Chronic Pain脥戮 Hyperalgesia脥戮 Allodynia脥戮 Glial Cells脥戮 Spinal Cord Plasticity脥戮 Peripheral Sensitization脥戮 Neuropathic Pain脥戮 Pain Management脥戮 Neuroinflammation
Citation: Iyer S (2025) Central Sensitization: A Key Chronic Pain Mechanism. jpar 14: 769. Doi: 10.4172/2167-0846.1000769
Copyright: © 2025 Suresh Iyer This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
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