Central Sensitization: Mechanisms, Therapeutics, and Future Directions
Received Date: Jul 01, 2025 / Published Date: Jul 29, 2025
Abstract
Central sensitization is a critical mechanism underlying chronic pain, characterized by amplified neuronal excitability in the central nervous system. This leads to heightened pain perception, allodynia, and hyperalgesia, significantly impacting quality of life. Glial cells and neuroinflammation are key contributors to this phenomenon. Therapeutic approaches encompass pharmacological interventions targeting neuronal hyperexcitability and inflammation, alongside non-pharmacological strategies such as physical therapy and CBT. Central sensitization is implicated in functional somatic syndromes, with emerging research on the gut-brain axis and genetic/epigenetic factors. Ongoing research continues to refine our understanding, emphasizing personalized pain management.
Keywords: Central Sensitization脥戮 Chronic Pain脥戮 Neuronal Excitability脥戮 Neuroinflammation脥戮 Glial Cells脥戮 Allodynia脥戮 Hyperalgesia脥戮 Pain Management脥戮 Functional Somatic Syndromes脥戮 Gut-Brain Axis
Citation: Osei DST (2025) Central Sensitization: Mechanisms, Therapeutics, and Future Directions. J Pain Relief 14: 762. Doi: 10.4172/2167-0846.1000762
Copyright: 2025 Dr. Samuel T. Osei This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
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