Central Sensitization: Understanding Chronic Pain Mechanisms
Received Date: Dec 01, 2025 / Published Date: Dec 29, 2025
Abstract
Central sensitization is a critical mechanism in chronic pain, involving nervous system hyperexcitability and amplified pain signaling. This condition can manifest as allodynia and hyperalgesia. Research highlights the roles of glial cells, neurotransmitters, epigenetic modifications, and multifactorial influences including genetics and psychological factors. Pharmacological and nonpharmacological interventions are being developed, with neuroimaging providing objective markers. Understanding the transition from acute to chronic pain is key for early intervention. Future directions include novel targets, refined diagnostics, and personalized therapies.
Keywords: Central Sensitization脥戮 Chronic Pain脥戮 Neuroinflammation脥戮 Glial Cells脥戮 Neurotransmitters脥戮 Epigenetics脥戮 Pain Management脥戮 Allodynia脥戮 Hyperalgesia脥戮 Neuroplasticity
Citation: Nakamura H (2025) Central Sensitization: Understanding Chronic Pain Mechanisms. jpar 14: 811. Doi: 10.4172/2167-0846.1000811
Copyright: 2025 Hiroshi Nakamura This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
Select your language of interest to view the total content in your interested language
Share This Article
Recommended Journals
Open Access Journals
Article Tools
Article Usage
- Total views: 156
- [From(publication date): 0-0 - May 22, 2026]
- Breakdown by view type
- HTML page views: 105
- PDF downloads: 51
