Chromatin Remodeling: Orchestrating Gene Expression and Disease
*Corresponding Author: Claire Dubois, Department of Epigenetics Brussels Institute of Biology, Belgium, Email: c.dubois@fakeuni.beReceived Date: Nov 03, 2025 / Published Date: Dec 01, 2025
Citation: Dubois C (2025) Chromatin Remodeling: Orchestrating Gene Expression and Disease. cmb 71: 415.DOI: 10.4172/1165-158X.1000415
Copyright: © 2025 Claire Dubois This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
Abstract
Chromatin remodeling is a fundamental epigenetic mechanism regulating gene expression by altering DNA accessibility through remodelers and histone modifications. This process is crucial for DNA repair, replication, and development, with its dysregulation implicated in diseases, particularly cancer. ATP-dependent remodelers, histone acetylation, DNA methylation, non-coding RNAs, nucleosome dynamics, histone variants, and chromatin’s role in DNA damage response and nuclear organization all contribute to this complex regulatory network. Mutations in chromatin remodeling genes are hallmarks of many cancers, presenting therapeutic opportunities.
