Chronic Rejection: Immunologic and Non-Immunologic Challenges
Received Date: Jan 02, 2025 / Published Date: Jan 30, 2025
Abstract
Chronic rejection in organ transplantation is a complex process driven by immunologic and non-immunologic factors. Alloantibodies and T-cell responses mediate immune-driven damage, while ischemia-reperfusion injury and drug toxicities contribute nonimmunologically. Histopathological changes like fibrosis and tubular atrophy are characteristic, and diagnostic criteria are refined through classifications like Banff. Emerging biomarkers and targeted therapies aim to improve early detection and management, ultimately enhancing long-term graft survival. Recurrent diseases and microbiome influences are also key considerations
Keywords: Chronic Rejection脥戮 Allograft Dysfunction脥戮 Immunologic Factors脥戮 Non-Immunologic Factors脥戮 Donor-Specific Antibodies脥戮 T-cell Mediated Rejection脥戮 Histopathology脥戮 Biomarkers脥戮 Immunosuppression脥戮 Therapeutic Strategies
Citation: Weber J (2025) Chronic Rejection: Immunologic and Non-Immunologic Challenges. J Clin Exp Transplant 10: 271. Doi: 10.4172/2475-7640.1000271
Copyright: © 2025 Johannes Weber This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
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