中国P站

Abstract

This body of research quantifies the global burden of congenital anomalies, revealing persistent high DALYs and mortality, espe cially in low-income regions. It highlights significant advancements in non-invasive prenatal testing, fetal diagnosis, and therapeutic interventions, alongside the clinical utility of genomic sequencing for definitive diagnoses. The work explores molecular genetics of specific conditions like CAKUT, environmental risk factors, and the critical role of maternal nutrition. It also addresses global public health priorities, ethical considerations in prenatal diagnosis, and the importance of multidisciplinary care for optimizing neurodevelopmental outcomes in affected children, particularly those with congenital heart disease.