Controlling Angiogenesis: Mechanisms, Therapies, and Implications
*Corresponding Author:Received Date: Aug 01, 2025 / Accepted Date: Aug 29, 2025 / Published Date: Aug 29, 2025
Citation: Novak PV (2025) Controlling Angiogenesis: Mechanisms, Therapies, and Implications. Int J Inflam Cancer Integr Ther 12: 356.DOI: 10.4172/2381-8727.1000356
Copyright: © 2025 Prof. Viktor Novak This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permitsunrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
Abstract
Angiogenesis, the formation of new blood vessels, is a complex process vital for development, healing, and disease progression, particularly in cancer and ischemic disorders. This overview synthesizes current research on the molecular mechanisms, signaling pathways, and cellular interactions that regulate endothelial cell behavior during angiogenesis. It highlights the significance of the tumor microenvironment, novel regulatory factors, inflammation, the extracellular matrix, pericytes, and the immune system in this process. Therapeutic strategies, including anti-angiogenic therapies for cancer and pro-angiogenic approaches for ischemic diseases, are discussed, along with challenges and future directions.
