中国P站

Abstract

Cytokines are key players in pain perception, modulating inflammatory and neuropathic pain through effects on nociceptors, ion channels, and neuronal excitability. Pro-inflammatory cytokines like TNF-α, IL-1β, and IL-6 contribute to pain, while antiinflammatory cytokines such as IL-10 and TGF-β offer analgesic effects. Neuroinflammation mediated by cytokines is central to chronic pain states. Specific cytokines, including IL-17A and TNF-α, have critical roles in inflammatory and neuropathic pain, respectively. The blood-brain barrier influences CNS cytokine access and neuroinflammation. Therapeutic strategies targeting cytokine pathways are under investigation for pain management, emphasizing the importance of cytokine balance

Keywords: Cytokines脥戮 Pain Perception脥戮 Neuroinflammation脥戮 Chronic Pain脥戮 Neuropathic Pain脥戮 Inflammatory Pain脥戮 Ion Channels脥戮 Blood-Brain Barrier脥戮 Analgesia脥戮 Cytokine Balance