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Early-Onset Juvenile Nasopharyngeal Angiofibroma: A Systematic Review

Received Date: Feb 28, 2025 / Published Date: Mar 30, 2025

Citation: Tsung-Lin Y (2025) Early-Onset Juvenile Nasopharyngeal Angiofibroma A Systematic Review. Otolaryngol (Sunnyvale) 15: 626.DOI: 10.4172/2161-119X.1000626

Copyright: © 2025 Tsung-Lin Y. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Juvenile nasopharyngeal angiofibroma (JNA) is a rare, benign, highly vascular tumor that predominantly affects adolescent males, with its peak incidence occurring between the ages of 10 and 20. However, early-onset JNA, defined as tumors diagnosed in patients younger than 10 years, is exceedingly rare and poses unique challenges in diagnosis and management. This systematic review aims to collate and analyze all reported cases of early-onset JNA to evaluate clinical presentation, diagnostic modalities, treatment options, and outcomes. We conducted a comprehensive search of multiple databases, including PubMed, Scopus, and Web of Science, for studies published between 1990 and 2024. A total of 28 studies were included, comprising 34 patients with early-onset JNA. Key findings highlight that early-onset JNA often presents with nonspecific symptoms, including nasal obstruction, epistaxis, and facial swelling, which can complicate early diagnosis. Imaging modalities, particularly contrast-enhanced CT and MRI, are essential for accurate diagnosis, while surgical excision remains the treatment of choice. The review underscores the importance of early recognition, as delayed treatment may lead to significant complications due to the tumor’s vascular nature. The clinical course, treatment efficacy, and recurrence rates in early-onset cases were found to be comparable to those in the general JNA population. This review provides valuable insights into the characteristics and management of early-onset JNA, emphasizing the need for further research to optimize treatment protocols and improve patient outcomes.