Fibromyalgia: Mechanisms, Treatments, and Future Directions
Received Date: Aug 04, 2025 / Published Date: Aug 29, 2025
Abstract
Fibromyalgia syndrome (FMS) is a chronic disorder marked by widespread pain, fatigue, and other symptoms. Central sensitization is a key pathophysiological mechanism. This review synthesizes recent advancements in understanding FMS, including genetic factors, gut microbiome alterations, and the influence of psychological stress. Therapeutic strategies encompass pharmacological treatments, Cognitive Behavioral Therapy (CBT), graded exercise therapy, and non-pharmacological interventions. Sleep disturbances and neuroinflammation are critical areas of focus for improved diagnosis and management
Keywords: Fibromyalgia Syndrome脥戮 Central Sensitization脥戮 Genetic Factors脥戮 Gut Microbiome脥戮 Psychological Stress脥戮 Cognitive Behavioral Therapy脥戮 Pharmacological Treatments脥戮 Graded Exercise Therapy脥戮 Sleep Disturbances脥戮 Neuroinflammation
Citation: Dupont C (2025) Fibromyalgia: Mechanisms, Treatments, and Future Directions. jpar 14: 773. Doi: 10.4172/2167-0846.1000773
Copyright: 2025 Claire Dupont This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
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