Gut Mucosal Immunity: Microbiome, Therapies, and Balance
Received Date: Jul 01, 2025 / Accepted Date: Jul 29, 2025 / Published Date: Jul 29, 2025
Abstract
This review explores the multifaceted landscape of mucosal immunity, focusing on the gut barrier. It highlights the critical roles
of specialized immune cells, including ILC3s and T cells, in maintaining intestinal homeostasis and responding to pathogens, and
discusses the implications of their dysregulation in diseases like IBD. The profound influence of the gut microbiome on immune
system development and function is examined, alongside advancements in mucosal vaccine strategies and the immune functions of
the intestinal epithelium. Furthermore, the review addresses aberrant mucosal immune responses, the significance of secretory IgA,
the contribution of ILCs, the interplay of diet and microbiome with immunity, and the regulatory roles of T cell subsets. Finally, it
touches upon precision medicine approaches to mucosal immunity.
Citation: Rossi DS (2025) Gut Mucosal Immunity: Microbiome, Therapies, and Balance. Immunol Curr Res 09: 266. Doi: 10.4172/icr.1000266
Copyright: © 2025 Dr. Sofia Rossi This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse, distribution and reproduction in any medium, provided the original author and source are credited.
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