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HPV-Driven Cervical Cancer: Genetic Drivers and Targeted Therapies

Dr. Ethan Walker^*

Harvard Medical School, USA

Received Date: Jun 04, 2025 / Published Date: Jun 30, 2025

Citation: Walker DE (2025) HPV-Driven Cervical Cancer: Genetic Drivers and Targeted Therapies. Current Trends Gynecol Oncol 10: 273.

Copyright: 漏 2025 Dr. Ethan Walker This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

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Cervical cancer pathogenesis involves a complex interplay of genetic mutations, prominently influenced by HPV infection. Key oncogenic pathways are impacted by alterations in genes such as TP53 and PIK3CA, affecting tumor aggressiveness and therapeutic resistance. HPV oncoproteins E6 and E7 are central to carcinogenesis. Research is uncovering novel mutations, epigenetic changes, and histological variations, driving the need for targeted therapies. Genomic instability is prevalent, and the tumor immune microenvironment is being investigated. Advanced tools like liquid biopsies offer diagnostic potential. Multi-omics integration is crucial for identifying precise therapeutic targets and biomarkers.