Immunology of Pain: Mechanisms and Therapies
Received Date: May 01, 2025 / Published Date: May 29, 2025
Abstract
This compilation of research delves into the immunological mechanisms driving pain and inflammation. It covers the role of inflammatory mediators, cytokines like IL-6 and TNF-alpha, and glial cell activation in sensitizing nociceptors and contributing to chronic pain. The influence of the gut microbiome, chronic stress, and autoimmune diseases on pain pathways is also explored. Furthermore, the therapeutic potential of mesenchymal stem cells and toll-like receptors as targets for pain management is discussed, alongside the intricate relationship between chronic pain and metabolic dysregulation. These studies collectively highlight key immunoinflammatory pathways relevant to pain and suggest diverse avenues for therapeutic intervention
Keywords: Inflammation脥戮 Pain脥戮 Immunology脥戮 Cytokines脥戮 Glial Cells脥戮 Microbiome脥戮 Chronic Stress脥戮 Autoimmune Diseases脥戮 Stem Cells脥戮 Toll- Like Receptors
Citation: Ricci P (2025) Immunology of Pain: Mechanisms and Therapies. J Pain Relief 14: 740. Doi: 10.4172/2167-0846.1000740
Copyright: 2025 Paolo Ricci This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
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