Inflammation and Immune Regulation: Molecular Signaling Pathways Unveiled
Received Date: Jul 01, 2025 / Accepted Date: Jul 29, 2025 / Published Date: Jul 29, 2025
Abstract
This compilation reviews pivotal signaling pathways in inflammation and immunity. It examines the NF-κB and JAK-STAT
pathways as central regulators of inflammatory gene expression and immune cell differentiation, respectively. The inflammasome’s
role in cytokine processing, MAPK pathways in stress responses, and PI3K/Akt in immune cell functions are detailed. The initiation
of inflammation via Toll-like receptors, the modulation of inflammatory responses by the complement system and sphingolipids, and
the concept of trained immunity are explored. The significant role of GPCRs in orchestrating inflammation and their therapeutic
relevance conclude the overview.
Citation: Wei DL (2025) Inflammation and Immune Regulation: Molecular Signaling Pathways Unveiled. Immunol Curr Res 09: 268. Doi: 10.4172/icr.1000268
Copyright: © 2025 Dr. Li Wei This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use,distribution and reproduction in any medium, provided the original author and source are credited.
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