Inflammation: Pervasive Disease Driver, Therapeutic Target
Abstract
This compilation reviews the central role of inflammation in diverse pathologies, including metabolic disorders, aging (”inflammaging”), neurodegeneration (Alzheimer’s disease), and cancer. It highlights how chronic inflammation, driven by factors like oxidative stress, gut dysbiosis, and immune dysregulation, contributes to disease progression. The data explores therapeutic strategies from pharmacological interventions and lifestyle changes to targeting specific mediators and utilizing pro-resolving molecules. Acute inflammatory responses, such as cytokine storms, are also discussed. The overarching theme emphasizes inflammation as a critical common pathway and a key therapeutic target for improving patient outcomes across various conditions.
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