Inflammation Resolution: SPMs Orchestrate Tissue Homeostasis and Repair
*Corresponding Author:Received Date: Oct 01, 2025 / Accepted Date: Oct 29, 2025 / Published Date: Oct 29, 2025
Citation: Rahman DY (2025) Inflammation Resolution: SPMs Orchestrate Tissue Homeostasis and Repair. Int J Inflam Cancer Integr Ther 12: 369.DOI: 10.4172/2381-8727.1000369
Copyright: © 2025 Dr. Yasmin Rahman This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permitsunrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
Abstract
Inflammation resolution is a crucial, active biological process vital for tissue homeostasis, mediated by specialized pro-resolving mediators (SPMs). These lipid mediators, including resolvins, protectins, and maresins, actively clear inflammatory cells and promote tissue repair. Dysregulation of resolution contributes to various diseases, from cardiovascular and neurodegenerative conditions to cancer. Therapeutic approaches enhancing SPM activity and cellular functions like efferocytosis offer significant promise for managing inflammatory and chronic diseases.
