Inflammatory Pain Mechanisms: Mediators, Cells, and Therapies
Received Date: Dec 01, 2025 / Published Date: Dec 29, 2025
Abstract
Inflammatory pain is driven by a complex interplay of mediators and cellular responses. This compilation reviews the roles of prostaglandins, cytokines, neuropeptides, TRP channels, glial cells, MMPs, and ROS in pain pathophysiology. It details mechanisms of peripheral and central sensitization and discusses therapeutic strategies targeting these mediators, including NSAIDs, cytokine inhibitors, and emerging approaches like TRP channel modulators and extracellular vesicle targeting, aiming to alleviate inflammatory pain.
Keywords: Inflammatory Mediators脥戮 Chronic Pain脥戮 Neuroinflammation脥戮 Cytokines脥戮 Prostaglandins脥戮 Neuropeptides脥戮 TRP Channels脥戮 Glial Cells脥戮 MMPs脥戮 ROS
Citation: Verma A (2025) Inflammatory Pain Mechanisms: Mediators, Cells, and Therapies. jpar 14: 810. Doi: 10.4172/2167-0846.1000810
Copyright: 2025 Ankit Verma This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited
Select your language of interest to view the total content in your interested language
Share This Article
Recommended Journals
Open Access Journals
Article Tools
Article Usage
- Total views: 136
- [From(publication date): 0-0 - May 22, 2026]
- Breakdown by view type
- HTML page views: 97
- PDF downloads: 39
