Insulin Sensitivity: Multifaceted Influences and Solutions
Received Date: Oct 01, 2025 / Published Date: Oct 29, 2025
Abstract
Insulin sensitivity is modulated by diverse factors including exercise, sleep, diet, gut microbiota, and environmental exposures. Exercise enhances sensitivity via sphingolipid metabolism, while sleep restriction impairs it. Dietary interventions, like intermittent fasting and managing inflammation, play crucial roles. The gut microbiota and epigenetic mechanisms dynamically influence glucose homeostasis. Mitochondrial dysfunction is a key driver of insulin resistance, especially in obesity. Metformin improves sensitivity through multifaceted actions. Understanding these interconnected influences is critical for developing effective strategies against insulin resistance and improving metabolic health
Citation: Petrova E (2025) Insulin Sensitivity: Multifaceted Influences and Solutions. jowt 15: 852.
Copyright: 漏 2025 E Petrova This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
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