Mechanisms and Management of Chronic Pain Pathways
Received Date: Aug 04, 2025 / Published Date: Aug 29, 2025
Abstract
Chronic pain is a complex condition driven by persistent activation of pain signaling pathways. This involves peripheral sensitization and central nervous system processing alterations, with significant contributions from neuroinflammation, glial cells, spinal cord plasticity, and ion channel function. Neurotrophic factors, the endocannabinoid system, and epigenetic modifications further modulate pain. The sympathetic nervous system, gut-brain axis, and brain network reorganization also play crucial roles. These interconnected mechanisms highlight the multifaceted nature of chronic pain and the need for comprehensive therapeutic approaches.
Keywords: Chronic Pain脥戮 Pain Signaling Pathways脥戮 Peripheral Sensitization脥戮 Central Neuroplasticity脥戮 Glial Cells脥戮 Spinal Cord Plasticity脥戮 Ion Channels脥戮 Neurotrophic Factors脥戮 Endocannabinoid System脥戮 Epigenetic Mechanisms
Citation: Sen R (2025) Mechanisms and Management of Chronic Pain Pathways. jpar 14: 764. Doi: 10.4172/2167-0846.1000764
Copyright: © 2025 Rahul Sen This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
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