Mechanisms and Therapies of Ischemia-Reperfusion Injury
Received Date: Dec 04, 2025 / Published Date: Jan 01, 2026
Abstract
Ischemia-reperfusion(I/R) injury is asignificant clinical challenge withdiverse underlyingmechanismsincludingoxidativestress, inflammation, ER stress, and cell death pathways. This review synthesizes research on I/R injury across multiple organs, highlighting the role of the innate immune system, microRNAs, and gut microbiota. Emerging therapeutic strategies targeting these mechanisms, such as novel antioxidants and stem cell therapies, show promise for mitigating damage and improving outcomes in transplantation and ischemic events.
Citation: Zhou DM (2026) Mechanisms and Therapies of Ischemia-Reperfusion Injury. troa 10: 329.
Copyright: 漏 2026 Dr. Mei-Ling Zhou This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permitsunrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
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