Mechanisms of Neuropathic Pain: A Complex System
Received Date: Aug 04, 2025 / Published Date: Aug 29, 2025
Abstract
Neuropathic pain arises from damage to the somatosensory nervous system, characterized by sensitization and altered pain modulation. Key molecular mechanisms involve ion channels, nerve growth factor, and glial cell-derived mediators like cytokines. Peripheral nerve injury leads to glial activation and neuronal hyperexcitability. Central sensitization in the spinal cord and brain amplifies pain signals. Understanding these pathways is essential for developing targeted therapies for this complex condition.
Keywords: Neuropathic Pain脥戮 Somatosensory Nervous System脥戮 Central Sensitization脥戮 Peripheral Sensitization脥戮 Ion Channels脥戮 Glial Cells脥戮 Cytokines脥戮 Nerve Growth Factor脥戮 Descending Pain Modulation脥戮 Autonomic Dysfunction
Citation: Mitchell L (2025) Mechanisms of Neuropathic Pain: A Complex System. jpar 14: 765. Doi: 10.4172/2167-0846.1000765
Copyright: © 2025 Laura Mitchell This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
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