Microbes, Metabolites, and Gut Inflammation Cascade
Received Date: May 01, 2025 / Published Date: May 29, 2025
Abstract
Microbial metabolites influence epithelial tight junction integrity, impacting mucosal inflammation. Specific metabolites modulate intestinal permeability and inflammatory responses. Dysbiosis alters metabolite production, increasing intestinal permeability. Short-chain \textit{Fatty Acids} (SCFAs) promote tight junction integrity. Certain bile acids disrupt epithelial tight junctions, triggering inflammation. Targeting microbial metabolites is a therapeutic strategy for managing inflammation and personalized interventions can restore epithelial barrier function.
Citation: Vogel M (2025) Microbes, Metabolites, and Gut Inflammation Cascade . J Mucosal Immunol Res 09: 302.
Copyright: 漏 2025 Markus Vogel This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
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