Migraine and Chronic Headache: Pathophysiology and Treatment
Received Date: Sep 01, 2025 / Published Date: Sep 29, 2025
Abstract
This review synthesizes current knowledge on chronic headache disorders, examining pathophysiology, genetic underpinnings, and therapeutic strategies. It covers migraine, migraine with aura, and cluster headaches, exploring neurobiological mechanisms including neuroinflammation and the gut-brain axis. Treatment modalities discussed range from pharmacological agents like CGRP inhibitors and onabotulinumtoxinA to non-pharmacological interventions such as neuromodulation. The impact of medication overuse headache and lifestyle factors is also highlighted, underscoring the importance of personalized and integrative approaches to patient care.
Keywords: Chronic Headache Disorders脥戮 Migraine脥戮 Pathophysiology脥戮 Treatment Strategies脥戮 Neuroinflammation脥戮 Gut-Brain Axis脥戮 Genetic Factors脥戮 Neuromodulation脥戮 Medication Overuse Headache脥戮 Cluster Headache
Citation: Ramos V (2025) Migraine and Chronic Headache: Pathophysiology and Treatment. jpar 14: 780. Doi: 10.4172/2167-0846.1000780
Copyright: © 2025 Victor Ramos This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
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