Neonatal HIE: New Strategies for Better Outcomes
Received Date: Oct 02, 2025 / Published Date: Oct 29, 2025
Abstract
Neonatal hypoxic-ischemic encephalopathy (HIE) is a critical condition impacting newborns. This review synthesizes recent
advancements in understanding HIE’s pathophysiology, molecular mechanisms, and therapeutic strategies. While therapeutic hy
pothermia is standard, emerging interventions like selective brain cooling and pharmacological approaches show promise. Research
explores cellular signaling, inflammation, oxidative stress, and the role of biomarkers for diagnosis and prognostication. Long-term
neurodevelopmental outcomes are influenced by various factors, necessitating robust follow-up care. Maternal health and resource
limitations add complexity to management. Advanced imaging and targeted neuroprotection, including addressing mitochondrial
dysfunction, are crucial for improving infant outcomes.
Citation: Rossi DA (2025) Neonatal HIE: New Strategies for Better Outcomes. NNP 11: 592.
Copyright: 漏 2025 Dr. Anna Rossi This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse, distribution and reproduction in any medium, provided the original author and source are credited.
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