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Abstract

Neonatal sepsis poses a critical global health challenge, characterized by diagnostic complexities, rising antimicrobial resistance,
and significant morbidity and mortality, particularly in Low- and Middle-Income Countries. This body of research examines its
epidemiology, underlying mechanisms, and current management, emphasizing the importance of early detection and appropriate
therapy. It highlights the potential of novel biomarkers to improve diagnostic accuracy and the necessity of standardized, evidence
based clinical practice guidelines. Furthermore, the long-term neurodevelopmental impacts of systemic inflammation are considered,
alongside the urgent need for tailored interventions in resource-limited settings to combat this leading cause of newborn mortality.