Neuroinflammation: Mechanisms, Impact, and Emerging Therapies
Received Date: Sep 02, 2025 / Published Date: Sep 30, 2025
Abstract
Neuroinflammation is a critical factor in the pathogenesis of numerous neurological disorders, involving resident immune cells
like microglia and astrocytes. While acute inflammationcanbeprotective, chronic inflammationleadstoneuronaldamage. Microglia
are key orchestrators, and astrocytes actively modulate inflammatory responses. The blood-brain barrier’s integrity is vital, and its
compromise exacerbates inflammation. Cytokines and chemokines are key mediators, with therapeutic strategies aiming to balance
their activity. Neuroinfectious diseases induce significant inflammation. Emerging therapies target inflammatory pathways and
immune cells. The gut-brain axis influences neuroinflammation, as do oxidative stress and mitochondrial dysfunction. Ongoing
research promises deeper insights and personalized therapeutic approaches
Citation: Evans DJ (2025) Neuroinflammation: Mechanisms, Impact, and Emerging Therapies. JNID 16: 592.
Copyright: 漏 2025 Dr. Julia Evans This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted聽use, distribution and reproduction in any medium, provided the original author and source are credited.
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