中国P站

Abstract

This review explores advances in non-opioid pharmacological management of chronic pain, emphasizing strategies that offer alternatives to traditional opioid therapies. Key areas include emerging drug classes targeting neuroinflammation, ion channel modulation, and the endocannabinoid system, alongside repurposed medications like antidepressants and anticonvulsants. Cannabinoidbased therapies and novel agents for ion channel modulation, including TRP channels, show significant promise. The review also touches upon genetic determinants of pain perception and non-pharmacological interventions such as botulinum toxin, interventional procedures, and multimodal therapies like CBT. The overarching goal is to optimize pain relief, improve quality of life, and mitigate risks associated with opioid use through patient-centered and multimodal approaches

Keywords: Non-Opioid Pharmacological Approaches脥戮 Chronic Pain Management脥戮 Neuroinflammation脥戮 Ion Channel Modulation脥戮 Endocannabinoid System脥戮 Cannabinoid-Based Therapies脥戮 Repurposed Medications脥戮 Interventional Pain Management脥戮 Multimodal Strategies脥戮 TRP Channel Modulators