中国P站

Abstract

Obesity profoundly increases cancer risk through diverse mechanisms, including adipose tissue inflammation, metabolic dysregulation, and altered immune responses. This condition drives carcinogenesis via molecular changes like altered hormones, chronic inflammation, and epigenetic modifications. The gut microbiome and conditions like MAFLD further contribute to cancer suscep-tibility. While obesity increases cancer incidence and therapeutic resistance, interventions such as bariatric surgery demonstrate significant potential in reducing obesity-related cancer risk. This highlights the critical need for strategies addressing obesity to mitigate its substantial impact on global cancer burden.