Optimizing Kidney Transplant: Personalized Immunosuppression Strategies
Received Date: Jan 02, 2025 / Published Date: Jan 30, 2025
Abstract
This collection of research highlights advancements in kidney transplant immunosuppression. Focus areas include personalized strategies, management of donor-specific antibodies (DSA), and novel immunosuppressive agents to balance efficacy and toxicity. Belatacept-based regimens show promise in improving renal function and reducing calcineurin inhibitor (CNI) side effects. Antibodymediated rejection (AMR) remains a challenge, with ongoing efforts to improve diagnostics and therapeutics. De-intensification of immunosuppression and pharmacogenomic approaches are explored for safer, individualized treatment. Infection risks and cardiovascular complications associated with immunosuppression are addressed. The pursuit of immunologic tolerance and effective de novo DSA management are key future directions.
Keywords: Kidney Transplantation脥戮 Immunosuppression脥戮 Donor-Specific Antibodies脥戮 Antibody-Mediated Rejection脥戮 Belatacept脥戮 Novel Immunosuppressive Agents脥戮 De-intensification脥戮 Pharmacogenomics脥戮 Immunologic Tolerance脥戮 Cardiovascular Risk
Citation: Moretti E (2025) Optimizing Kidney Transplant: Personalized Immunosuppression Strategies. J Clin Exp Transplant 10: 264. Doi: 10.4172/2475-7640.1000264
Copyright: © 2025 Elena Moretti This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited
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