中国P站

Abstract

Osteonecrosis, also known as avascular necrosis (AVN), is a debilitating condition that results from the compromised blood supply to the bone, leading to bone tissue death and eventual structural collapse. Its prevalence is notably increasing among oncology and transplant patients, primarily due to the widespread use of high-dose corticosteroids, chemotherapy, immunosuppressive agents, and radiation therapy. As cancer survival rates improve and organ transplantation becomes more common, the long-term complications like osteonecrosis are becoming more evident. This article delves into the pathophysiology, risk factors, diagnostic approaches, and management strategies for osteonecrosis in oncology and transplant populations, underscoring the importance of early recognition, preventive strategies, and multidisciplinary care in mitigating its impact on quality of life.