Ovarian Cancer: Tumor Suppressor Genes, Mutations, and Therapies
Received Date: Aug 01, 2025 / Published Date: Aug 29, 2025
Abstract
Tumor suppressor genes are critical in preventing ovarian cancer by regulating cell growth, DNA repair, and apoptosis. Mutations in key genes like TP53, BRCA1, and BRCA2 disrupt these processes, leading to uncontrolled proliferation. Understanding these mechanisms is vital for developing targeted therapies. Germline BRCA mutations are significant risk factors, and PARP inhibitors are a major treatment option. Beyond well-known genes, other tumor suppressors and epigenetic silencing also contribute to ovarian cancer. The tumor microenvironment and molecular heterogeneity influence disease progression and treatment. Functional genomics and liquid biopsies are advancing the identification of therapeutic targets and personalized treatment strategies.
Citation: James DO (2025) Ovarian Cancer: Tumor Suppressor Genes, Mutations, and Therapies. Current Trends Gynecol Oncol 10: 286.
Copyright: 漏 2025 Dr. Olivia James This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
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