Overcoming Chemoresistance in Ovarian Cancer: Novel Strategies
Received Date: Dec 01, 2025 / Published Date: Dec 29, 2025
Abstract
Chemoresistance significantly impacts ovarian cancer treatment outcomes, often leading to relapse. This review consolidates insights into the multifaceted mechanisms driving this resistance. Key contributors include genetic alterations, epigenetic modifications, the tumor microenvironment, and cellular plasticity such as epithelial-mesenchymal transition and cancer stem cells. Molecular mechanisms involving drug efflux pumps and DNA damage repair pathways are also critical. Understanding these complex interactions is vital for developing novel therapeutic strategies, including targeted therapies and combination treatments, to improve patient prognosis
Citation: Bell DH (2025) Overcoming Chemoresistance in Ovarian Cancer: Novel Strategies. Current Trends Gynecol Oncol 10: 309.
Copyright: 漏 2025 Dr. Henry Bell This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited
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