Overcoming Ovarian Cancer Chemoresistance: A Multifaceted Approach
*Corresponding Author: Dr. Liam Patel, University of Toronto, Canada, Email: liampatel@yahoo.comReceived Date: Jun 04, 2025 / Published Date: Jun 30, 2025
Citation: Patel DL (2025) Overcoming Ovarian Cancer Chemoresistance: A Multifaceted Approach. Current Trends Gynecol Oncol 10: 275.
Copyright: 漏 2025 Dr. Liam Patel This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited
| Peer-reviewed Full Article 
Abstract
Chemotherapy resistance remains a significant hurdle in ovarian cancer treatment, leading to recurrence and poor outcomes. Resistance arises from mechanisms like altered drug metabolism, enhanced DNA repair, and survival pathway activation. The tumor microenvironment, epigenetic modifications, cancer stem cells, and drug efflux pumps also play critical roles. Emerging strategies focus on combination therapies, targeting specific resistance pathways, and utilizing immunotherapy. Liquid biopsies offer real-time monitoring of resistance. Understanding these complex mechanisms is vital for developing novel approaches to re-sensitize tumors and improve patient survival
