中国P站

Abstract

Oxidative stress is a critical factor in numerous pathologies, including neurodegeneration, cancer, cardiovascular diseases, diabetes, and age-related conditions. This comprehensive body of work highlights how reactive oxygen species damage cells, disrupt redox homeostasis, and fuel inflammation. It outlines the specific mechanisms underpinning these diseases, from mitochondrial dysfunction to gut microbiota interactions. Importantly, various therapeutic strategies are explored, including synthetic and natural antioxidants, Nrf2 pathway modulators, and mitochondrial-targeted interventions. Understanding these multifaceted roles of oxidative stress is vital for developing effective, targeted treatments and fostering healthy aging across diverse human diseases.