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Abstract

This compilation of research examines the intricate links between chronic pain and depression, investigating shared neurobiological, psychological, and environmental factors. It explores the efficacy of various interventions, including exercise, CBT, MBSR, and pharmacotherapy, underscoring the importance of personalized treatment plans. The impact of inflammation, neurotransmitter dysregulation, social isolation, and sleep disturbances are also discussed. The findings advocate for comprehensive, integrated approaches to effectively manage these comorbid conditions.

Keywords: Chronic Pain脥戮 Depression脥戮 Comorbidity脥戮 Neurobiological Pathways脥戮 Psychological Factors脥戮 Exercise Therapy脥戮 Cognitive Behavioral Therapy脥戮 Mindfulness脥戮 Pharmacotherapy脥戮 Inflammation