中国P站

Abstract

Pancreas transplantation provides substantial metabolic benefits for type 1 diabetes patients, leading to insulin independence and better glycemic control. However, graft survival, immunosuppression, and recurrence of diabetes influence long-term outcomes. Simultaneous pancreas-kidney transplantation remains a cornerstone for specific patients, improving cardiovascular risk and reducing diabetes complications. Immunosuppression management critically impacts metabolic control, with research exploring steroidsparing agents to combat new-onset diabetes after transplantation and dyslipidemia. Allograft rejection is a key factor affecting metabolic success. Quality of life improves significantly post-transplant. The complex metabolic profile requires careful management of graft function, immunosuppression, and comorbidities. Future research focuses on optimizing organ use, preventing allograft damage, and refining immunosuppression for improved metabolic outcomes.

Keywords: Pancreas Transplantation脥戮 Type 1 Diabetes脥戮 Insulin Independence脥戮 Glycemic Control脥戮 Immunosuppression脥戮 New-Onset Diabetes After Transplantation脥戮 Graft Survival脥戮 Quality of Life脥戮 Metabolic Outcomes脥戮 Simultaneous Pancreas-Kidney Transplantation