Pattern Recognition Receptors: Immunity, Disease, and Therapeutics
Received Date: Jul 01, 2025 / Accepted Date: Jul 29, 2025 / Published Date: Jul 29, 2025
Abstract
Pattern recognition receptors (PRRs) are central to innate immunity, sensing danger signals and initiating inflammatory and
antiviral responses. This collection of research highlights diverse PRRs including TLRs, NLRs, RLRs, and CLRs, exploring their
roles in immunity and their implications in diseases like autoimmunity, cancer, and infections. Specific studies detail TLR4 signaling,
NLRP3 inflammasome activation, RLR-mediated antiviral immunity, and CLR functions in microbial recognition. The interplay of
PRRs with the tumor microenvironment, gut microbiota, and neuroinflammation is examined. Furthermore, the regulation of PRR
function through epigenetic modifications and their involvement in metabolic diseases are discussed, underscoring their broad impact
and therapeutic potential.
Citation: Brown DH (2025) Pattern Recognition Receptors: Immunity, Disease, and Therapeutics. Immunol Curr Res 09: 274. Doi: 10.4172/icr.1000274
Copyright: © 2025 Dr. Helen Brown This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse, distribution and reproduction in any medium, provided the original author and source are credited.
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