中国P站

Abstract

Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating disease of the central nervous system caused by the
JC virus (JCV), primarily affecting immunocompromised individuals. Diagnosis relies on clinical, imaging, and CSF findings. The
incidence of PML has increased with immunosuppressive therapies, prompting research into risk mitigation and novel treatments.
Current therapeutic strategies include immune reconstitution and antiviral agents, but effective treatments remain limited. PML man
agement requires careful consideration of underlying immunosuppression and potential complications like IRIS. Long-term sequelae
can impact quality of life, necessitating rehabilitation. Ongoing research aims to elucidate JCV pathogenesis and develop targeted
therapies