中国P站

Abstract

Progressive Supranuclear Palsy (PSP) was first reported as a new syndrome and this original phenotype of PSP is called PSP-Richardson Syndrome (PSP-RS). Since then, nine different clinical phenotypes have been documented in addition to PSP-RS according to the Movement Disorder Society (MDS) criteria for PSP. However, the phenotype of PSP associated with idiopathic Normal Pressure Hydrocephalus (iNPH) has not yet been accepted, although a considerable number of patients with their combination have been reported based on pathological or clinical evidence. Herein, I report a patient presenting with PSP associated with iNPH (PSP-iNPH). Definite iNPH of this patient was diagnosed based on the Japanese diagnostic criteria for iNPH. Several disorders involving Central Nervous System (CNS) are known to coexist with iNPH and iNPH in PSP is probably induced by abnormal CerebroSpinal Fluid (CSF) dynamics due to CNS tauopathy of PSP. As the coexistence of PSP and iNPH seems to be more common than the combination of iNPH and other neurodegenerative diseases, PSP-iNPH syndrome might be accepted as a new clinical form of PSP.